The following detection tools and resources are available:
The Cert Graveyard YARA project is an automated tool to collect updates to the Cert Graveyard database and automatically generate YARA rules: The Cert Graveyard YARA by TJNel
Microsoft Defender for Endpoint (MDE) allows the user to pull external data for running Kusto queries. This can be used to pull the Cert Graveyard database for detection purposes. In the queries in this GitHub repository, this method is demonstrated to use the database to look for the presence of malicious files: queries in Detection Engineering & Threat Hunting (DE&TH) by SecurityAura